Archive for the ‘Cancer’ Category

Promising Results from Human Colon/Liver Cancer Study

Saturday, June 18th, 2011
British scientists at the Department of Cancer Studies at the University of Leicester have just published promising Phase 1 results from a double blind study where resveratrol was administered to patients with colorectal cancer which has spread to their livers (i.e. hepatic metastases).
 
In the study, 5 grams of micronized resveratrol (micronization is the process of making molecules of a substance very small in order to increase absorption into the body) were given orally to a group of patients while another group received a placebo. This course of treatment lasted 14 days. 
 
Not only were the large doses of resveratrol well tolerated by the patients, but there is indication that liver cancer cell apoptosis (a process where the cells essentially destroy themselves) increased an impressive 39%.  Unfortunately, the patients receiving the placebo did not experience this benefit.
 
Editor’s Note: this study is interesting for three reasons:
  • The indication that apoptosis increased 39% in resveratrol treated patients is very promising as the 5 year survival rate of patients with colorectal cancer that has spread to the liver is around 5%. Further, about 20% of all diagnosed colorectal cancer cases in the United States (i.e. 30,000 cases/year) involve metastases to the liver;
 
  •  It demonstrates that resveratrol taken orally can reach organs of the body – and therefore treat them. From the study, “Resveratrol was detectable in hepatic tissue …up to 2287 ng/g”; and,
 
  • Micronization improves absorption of resveratrol into the body; micronization of resveratrol increased mean plasma levels by 3.6 fold over non micronized resveratrol.

Resveratrol Prevents Cancer Induced Muscle Wasting

Saturday, June 11th, 2011
Scientists at the University of North Carolina School of Medicine revealed for the first time that Resveratrol protects against cancer induced skeletal muscle loss and cardiac atrophy (i.e. wasting). 
In the study, mice with Adenocarcinomas (cancers of the tissues that form numerous glands and line the cavities and surfaces of the body) were fed resveratrol. The results of the study revealed less skeletal muscle loss and wasting in the heart muscle than mice not fed resveratrol. 
Editor’s Note: it is believed that severe wasting is responsible for 1/3 of all cancer deaths. What’s more, adenocarcinomas, as alluded above, develop in many areas of the body including the colon, lungs, pancreas, prostate, cervix, esophagus, and stomach. From the results of this study it is plausible that resveratrol - along with fighting cancer by neutralizing free radicals, protecting the integrity of DNA, and reducing inflammation – also can help cancer patients by preventing dangerous wasting.  

Resveratrol Protects Against Radiation Exposure

Wednesday, March 16th, 2011

Scientists at the University of Pittsburg determined that resveratrol can protect against radiation exposure.  Specifically, resveratrol was given to mice before exposure to radiation; the mice given the resveratrol were protected from cell damage due to radiation.

According to the study’s author, Joel Greenberger, M.D., professor and chairman of the Department of Radiation Oncology at the University of Pittsburgh School of Medicine, "New, small molecules with radioprotective capacity will be required for treatment in case of radiation spills or even as countermeasures against radiological terrorism…Small molecules which can be easily stored, transported and administered are optimal for this, and so far acetylated resveratrol fits these requirements well."

New Study Reveals Resveratrol Could Be Used to Fight Breast Cancer

Monday, February 14th, 2011
A new study just released by researchers at the Cleveland Clinic reveals that resveratrol, when administered in combination with rapamycin (a drug with immunosuppressant effects considered to be a potentially promising breast cancer treatment), was twice as effective in killing breast cancer cells as when rapamycin was administered alone. In effect, the resveratrol prevented the breast cancer cells from becoming resistant to rapamycin.   According to the study’s lead, Charis Eng, MD and Ph.D., "Rapamycin has been used in clinical trials as a cancer treatment.  Unfortunately, after a while, the cancer cells develop resistance to rapamycin…Our findings show that resveratrol seems to mitigate rapamycin-induced drug resistance in breast cancers…”
 What’s more, the study also administered resveratrol alone (without rapamycin) to the breast cancer cells and found that resveratrol slowed or stopped their growth in a dose dependent manner.
This study concluded that resveratrol might be a “powerful integrative medicine adjunct to traditional chemotherapy.” 
Editor’s Note: Past studies have revealed that resveratrol prevents the first step that occurs when estrogen begins the process that leads to breast cancer and that resveratrol also strongly inhibits BRCA1-mutant tumor growth.   

More Positive Resveratrol Cancer News

Wednesday, November 3rd, 2010
Two recent studies add to the growing body of evidence that resveratrol may prevent or fight various forms of cancer.  
Specifically, one study published in the journal BMC Cancer concluded that resveratrol, in vitro, repressed the expression of the YKL-40 gene which is one of the most over-expressed genes in Glioblastoma multiforme (GBM) brain tumors (patients with GBM brain tumors have one of the worst survival rates of any brain tumor patients).
In another in vitro study, Chinese scientists concluded that resveratrol inhibits the proliferation of various lines of pancreatic cancer cells through apoptosis (preprogrammed cell death). Pancreatic cancer is one of the most deadly forms of cancer in humans.
Editor’s Note: Resveratrol has also show promise in cancers of the breast, lung, prostate, skin, colon, and blood (e.g. leukemia).

Resveratrol Fights Colon Cancer Proliferation in Humans

Monday, November 1st, 2010
A study of 20 adult colon cancer patients revealed that resveratrol may be an effective weapon against colon cancer. Specifically, the study found that an oral dose of as little 500 mg. per day, given 8 days before surgery, was effective in reducing cancer cell proliferation.
Editor's Note: this is another human study that indicates resveratrol's anticancer effects AND that these effect may be achieved at doses far less than previously reported.

Resveratrol Protects Lung Cells From Damage From Cigarette Smoke

Tuesday, May 25th, 2010

Scientists at the University of Rochester pretreated the lung cells of one group of mice with resveratrol (a SIRT1 activator) while pretreating the lung cells of another group of mice with sirtinol (a SIRT1 inhibitor).  The researchers then exposed the lung cells of both groups of mice to cigarette smoke.  The mice that were pretreated with resveratrol had less lung damage than the mice pretreated with the SIRT1 inhibitor.  Might resveratrol be used to reduce lung damage of smokers?

Resveratrol Helps Treat Ulcerative Colitis and Prevent Colon Cancer

Monday, March 29th, 2010

In a recent study some mice with ulcerative colitis (an inflamatory disease of the large intestine) were given resveratrol in their food while other mice with the disease were not given resveratrol.  Not only did the mice fed resveratrol have less incidence of ulcerative colitis (e.g. less inflammation), but they had a 60% less chance of contracting colon cancer than the mice not fed resveratrol. 


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