Archive for the ‘Colon Cancer’ Category

Promising Results from Human Colon/Liver Cancer Study

Saturday, June 18th, 2011
British scientists at the Department of Cancer Studies at the University of Leicester have just published promising Phase 1 results from a double blind study where resveratrol was administered to patients with colorectal cancer which has spread to their livers (i.e. hepatic metastases).
In the study, 5 grams of micronized resveratrol (micronization is the process of making molecules of a substance very small in order to increase absorption into the body) were given orally to a group of patients while another group received a placebo. This course of treatment lasted 14 days. 
Not only were the large doses of resveratrol well tolerated by the patients, but there is indication that liver cancer cell apoptosis (a process where the cells essentially destroy themselves) increased an impressive 39%.  Unfortunately, the patients receiving the placebo did not experience this benefit.
Editor’s Note: this study is interesting for three reasons:
  • The indication that apoptosis increased 39% in resveratrol treated patients is very promising as the 5 year survival rate of patients with colorectal cancer that has spread to the liver is around 5%. Further, about 20% of all diagnosed colorectal cancer cases in the United States (i.e. 30,000 cases/year) involve metastases to the liver;
  •  It demonstrates that resveratrol taken orally can reach organs of the body – and therefore treat them. From the study, “Resveratrol was detectable in hepatic tissue …up to 2287 ng/g”; and,
  • Micronization improves absorption of resveratrol into the body; micronization of resveratrol increased mean plasma levels by 3.6 fold over non micronized resveratrol.

Resveratrol Fights Colon Cancer Proliferation in Humans

Monday, November 1st, 2010
A study of 20 adult colon cancer patients revealed that resveratrol may be an effective weapon against colon cancer. Specifically, the study found that an oral dose of as little 500 mg. per day, given 8 days before surgery, was effective in reducing cancer cell proliferation.
Editor's Note: this is another human study that indicates resveratrol's anticancer effects AND that these effect may be achieved at doses far less than previously reported.

Resveratrol Helps Treat Ulcerative Colitis and Prevent Colon Cancer

Monday, March 29th, 2010

In a recent study some mice with ulcerative colitis (an inflamatory disease of the large intestine) were given resveratrol in their food while other mice with the disease were not given resveratrol.  Not only did the mice fed resveratrol have less incidence of ulcerative colitis (e.g. less inflammation), but they had a 60% less chance of contracting colon cancer than the mice not fed resveratrol. 

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