Archive for the ‘Heart Health’ Category
Researchers at Michigan State University recently published a study in the American Journal of Physiology – Regulatory, Integrative, and Comparative Physiology that revealed resveratrol reverses increases in blood pressure due to chronic estrogen exposure. Many women take estrogen as a means to combat menopause (known as hormone replacement therapy – HRT). Estrogen is also found in small amounts in birth control pills.
In the study, the researchers injected mice with estrogen. The researchers noticed that the estrogen significantly increased the animals’ blood pressures – most likely through the buildup of superoxide in the brain. The researcher then fed resveratrol to the mice and their blood pressures (and superoxide levels) returned to their levels before the estrogen injections.
High blood pressure, also known as hypertension, is a contributing factor to numerous health problems including heart attack, congestive heart failure, stroke, poor or lost vision, brain damage, and kidney disease.
A study presented at the American Heart Association conference by researchers from LSU revealed that resveratrol coated stents blocked the narrowing of blood vessels and led to less inflammation. According to the researchers, current drug coated stents "are still limited as far as pharmacologic targets. These polyphenols may lead us to explore other targets because they are hitting so many different things…that increase reendothelialization." (Note: Reendothelialization is the regrowth of endothelial tissue following damage). Also, the study revealed the both low and high doses of resveratrol were effective in promoting reendothelialization as compared to bare metal stents. The study also revealed that resveratrol promoted endothelial cell wound closure under laminar shear stress.
Commenting on the results of the study, Dr. Philippe Marambaud of the Feinstein Institute for Medical Research said, "There's overwhelming evidence that this compound has very powerful properties."
Editor’s Note: the results of this study are not surprising considering the numerous past studies that have shown resveratrol and red wine improve heart function and blood vessel health.
Australian researchers revealed results of a study where 99% pure resveratrol (resVida branded product) improved human cardiovascular performance. In the study, 14 overweight men and 5 postmenopausal women all with hypertension were given 3 doses of resveratrol (either 30, 70, or 270 mg.) per day. The participants who received the 30 mg. dose experienced a 62% increase in the diameter of their arteries whereas the participants who received a 270 mg. dose experienced a 91% increase (an increase in artery diameter, which increases blood flow, is known as flow-mediated dilatation. Flow-mediated dilatation is linked to the healthy functioning of the cardiovascular system).
Editor’s Note: this study is just another indication that resveratrol can be healthy for human hearts. According to the resveratrol manufacturer resVida, they are planning, or are conducting, several more human resveratrol studies. As the results of an increasing number of human studies are released, the health benefit of resveratrol supplementation is looking very promising.