Resveratrol Side Effects

According to tests conducted by Sirtris Pharmaceuticals, human subjects experienced no serious side effects or dose-related side effects when taking 2.5 grams or 5 grams of resveratrol per day for 28 days (note: a small human study released in June of 2010 revealed that resveratrol at 4 grams/day induced diarrhea).  Further, the Environmental Protection Agency considers resveratrol to be non toxic and the National Institute of Environmental Health Sciences commissioned a study that found “adverse affects of resveratrol have not been reported” and “a …dosage of 5-10 Mg… per day was stated to be entirely safe.” But while resveratrol appears safe for short term use, even at high doses (e.g. 2.5 to 5 grams/day), there are still unknowns about the long term side effects of high dose resveratrol. (Note: low doses of resveratrol have been consumed in wine and other natural foods for thousands of years – see the Sources of Resveratrol tab).  Further, science is still determining how resveratrol reacts with other drugs.  This uncertainty stems, in part, from the fact that resveratrol slows the speed at which livers break down common drugs.

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