Sirtuin Activating Drug Increases Lifespan in Obese Mice

An experimental GlaxoSmithKline (GSK) drug designed to mimic resveratrol’s sirtuin activating properties has been found to extend the lifespan of obese mice by about 44% according to a recent study conducted by the National Institute on Aging. This study again shows the positive health effect of activating sirtuins (please see the “Life Extension” section of for more information on the benefits of sirtuin activation). 
Editor’s Note:  The really interesting take away/reminder  from this study is that Resveratrol, a naturally occurring compound, which has very little - if any - known  negative side effects, was found in 2006 – by the Same Researchers – to extend the lifespan of obese mice by 31%.
Resveratrol is available for sale now- unlike the drug used in the study. What’s more, according to GSK, the drug used in the trial will not even be offered to the public; they are going to develop another, similar, drug that is more suitable for human consumption.   Further, the dosage equivalent from the above mentioned 2006 resveratrol mouse study can be met with two 1000 mg. 98% pure resveratrol pills per day (the size of 2 ‘standard’ fish oil pills per day). 
And if you would like to take a lower dose of resveratrol, there is also good news. Harvard scientist David Sinclair, who led the 2006 study, stated that the high fat diet mice, on the equivalent of 300 mg. of resveratrol per day, showed similar, but less dramatic, results as the ones fed the larger resveratrol doses mentioned above. Further, many recent studies are revealing that a relatively low dose ofresveratrol is effective in fighting heart disease, diabetes, and inflammation (Please see the “Resveratrol Dosage” and “Resveratrol Side Effects” section of for more information ).

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